Allergic-like reactions can occur in patients (both children and adults) when given gadolinium containing contrast agents, even if they have been pre-medicated with corticosteroids and antihistamines, according to a recent study conducted by researchers at the University of Michigan Health Systems in Ann Arbor.”We pre-medicate patients at our institution who have a history of prior allergic-like reaction to gadolinium-containing contrast agents”, said Jonathan R.