BCL2 Reins In BIM, Preventing Leukemic Cell Death
Cancer is caused when a population of cells starts to grow in an inappropriate and uncontrolled manner. In many cancers the tumor cells express increased levels of a family of proteins (that includes BCL2 and MCL1) that protect them from a form of cell death known as apoptosis. Exactly how these proteins are important for tumor cell survival, and thereby inappropriate and uncontrolled growth, has not been completely clear. [click link for full article]