UroToday.com - Tumor angiogenesis have shown to be correlated with metastasis in invasive prostate carcinoma1. In-vitro inhibition of Ras/Raf pathway has shown growth arrest and cell death of LNCaP and PC-3 prostate cancer cell lines2 and in a separate study modulation of this pathway have been implicated in restoring the sensitivity to hormonal interventions, in-vitro3.